Questions About Nitric Oxide

1. What is nitric oxide?

   Nitric oxide (NO) is a well-understood, well-studied nano-molecule that naturally occurs in the body. It has several physiological functions, including dilating blood vessels and helping regulate the immune response to infection. First approved in 1999 to treat blue baby syndrome (persistent pulmonary hypertension of the newborn), NO has also been extensively studied for its antimicrobial properties. SaNOtize studies show that, when delivered in the right concentration and duration, NO can kill pathogens while remaining safe for human cells.

2. How does nitric oxide kill pathogens?

   Nitric oxide (NO) has multiple mechanisms of action (MOA) as an antimicrobial. As an antiviral, NO prevents viruses from entering cells and replicating, inactivating them through changes to spike proteins and proteases. In bacteria and fungi, NO damages DNA, inhibits DNA repair, and causes lipid damage via lipid peroxidation. These mechanisms make NO an effective broad-spectrum antimicrobial with a low likelihood of resistance, all while being safe for human cells.

Questions About Nitric Oxide Nasal Spray (NONS^TM)

Please refer to the User Guide for additional information.

3. Where can I purchase enovid^TM / VirX^TM?

   The spray is available in Israel and Indonesia as enovid^TM, and as VirX^TM in Thailand, Singapore, Hong Kong, South Africa, Malaysia, Cambodia, and Germany. It is also sold under prescription in India as FabiSpray.

   Not available for sale in Canada or the U.S. at this time.

4. What is the difference between enovid^TM and VirX^TM?

   They are the same product, marketed under different names in various countries. NONS (Nitric Oxide Nasal Spray) is the generic name.

5. Can I trust third-party sellers like eBay?

   SaNOtize accepts no responsibility or liability for products not purchased through authorized distributors or retail outlets.

6. What do benchtop lab results show against SARS-CoV-2?

   Lab tests show nitric oxide inactivates >99.9% of SARS-CoV-2, including all tested variants, within two minutes of contact. The spray has also been studied against Influenza (H1N1), RSV, and Rhinovirus.

   

7. What are the key clinical results for COVID-19?

   Clinical trials showed a >95% reduction in viral RNA load within 24 hours, and >99% within 48–72 hours. Time to PCR-negative was halved in high-risk groups.

   • The Lancet, July 2022
   • Journal of Infection, May 2021
   • Respiratory Therapy, Spring 2023

8. How does the spray work?

   The proprietary spray creates a measurable dose of nitric oxide when released. Watch the mechanism of action.

9. How do I use it?

   2 alternating sprays per nostril, 3–4 times daily. Up to 6 uses per day. Refer to the User Guide.

10. Are there side effects?

    Side effects may include headache, nosebleed, or burning sensation. Discontinue use and consult a healthcare provider if symptoms persist.

11. Is it safe for children?

    Approved for children 12 and older. Consult a healthcare provider for younger children.

12. Will it interfere with COVID-19 tests?

    The spray does not interfere with PCR or antigen tests, though it may still trigger a positive result immediately after use due to inactive virus particles.

13. Is long-term use safe?

    Initial data suggests a safe profile. Long-term studies are underway.

14. Are there drug interactions?

    None known. Avoid other nasal sprays within 2 hours. Do not use around the time of live nasal vaccines (e.g., FluMist).

15. Can it be used during pregnancy?

    Not currently approved for use during pregnancy or breastfeeding. Consult a healthcare provider.

16. Does it contain harmful ingredients?

    No. It does not contain steroids or graphene. Key ingredients: sodium chloride, citric acid, sodium nitrite, benzalkonium chloride.

17. What preservatives are used?

    Benzalkonium chloride (0.01%).

18. What is the shelf life of an unopened bottle?

    Refer to the printed expiry date on the bottle.

19. How long is it good for after opening?

    Guaranteed stable for 60 days after opening.

20. What if the bottle malfunctions?

    Return it to the authorized retailer for a replacement.

21. What if I experience health issues?

    Stop using the product and consult a healthcare provider. Report issues to info@sanotize.com.

22. What’s the difference between lab and clinical data?

    Lab data refers to in vitro testing (e.g. 99.9% virus inactivation). Clinical data reflects human trials (e.g. 95% reduction in viral load within 24 hours).

23. Why does it sting sometimes?

    Nasal sensitivity may vary due to timing, user preparation, or frequency of use.

24. Is nitric oxide the same as nitrous oxide?

    No. This product does not contain nitrous oxide (N₂O). For a comparison, click here.

25. How can I contact SaNOtize?

    Email us at info@sanotize.com or contact an authorized distributor.