Recruiting for COVID clinical trial

Our aim is to utilize the unique antimicrobial and immunomodulating properties of NO to treat both dermatologic and respiratory disease

Mechanisms of Action

Antibacterial – NO Interferes with DNA repair mechanisms, nitrosylating heme-containing or thiol-containing metabolic proteins, damages membrane lipids, or modulates the host immune response

Antiviral – After nitrosylating cysteine moieties, NO likely causes conformational changes on surface glycoproteins that can interfere with host cell fusion, preventing infection and release of virions from already infected host cells, similar to neuraminidase inhibitors

In the cell – NO interferes with mRNA transcription and replication via inhibition of either viral ribonucleotide or viral RNA synthesis

Antifungal – The antifungal effect of NO is likely a result of nitrosylation of cysteine sites which leads to protein structural changes that interferes with basic enzymatic and/or catalytic activity

Anti-inflammatory – NO inhibits the synthesis of most pro-inflammatory mediators (cytokines) and promotes the synthesis of anti-inflammatory cytokines

Increase blood flow – Potent selective vasodilator effect caused by smooth muscle relaxation in response to increased cGMP and decreased Ca2+ ion influx in smooth muscle cells; inactivated by phosphodiesterase and binding to hemoglobin

Enhanced wound healing – While high dose NO works as an antimicrobial, low dose NO promotes increased collagen formation, increased blood flow, and up-regulates growth factors

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