Recruiting for COVID clinical trial

Sinusisitis, or rhinosinsitis, is an inflammation of the sinuses causing a range of symptoms that include plugged nose, thick nasal mucosa, facial pain, fever and headaches. Infectious causes of sinusitis can be bacterial, viral or fungal. Typical causative microbes include rhinovirus, coronavirus, influenza viruses and adeno viruses, as well as Streptococcus pneumoniae and Haemophilus influenzae.

Chronic rhinosinsitis affects 12% of the American population below the age of 45 years. Current therapies include antimicrobials, corticosteroids, decongestants, antihistamines, mast cell stabilizers, antileukotrienes, nasal douching, immunotherapy and avoidance of specific environmental factors. When sinusitis is refractory to conventional therapy, functional endoscopic sinus surgery (FESS) has a 76% success rate to alleviate symptoms over a 1-3 year follow-up period.

The SaNOtize team believes that NORSTM may be especially effective as a nasal lavage for treating sinusitis, regardless of infectious etiology. In vitro studies have shown the efficacy of NO and NO delivered through NORSTM against many strains of bacteria, viruses and fungi associated with sinusitis.

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